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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0152 | Bosutinib | SKI-606 | Bcr-Abl , Src , Autophagy |
Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases. | |||
T2640 | Rebastinib | DCC2036,DCC 2036,DCC-2036 | Apoptosis , FLT , Bcr-Abl , Src |
DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re... | |||
T3063 | PD173955 | PD-173955,PD 173955 | Apoptosis , Bcr-Abl , Src |
PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC. | |||
T17267 | XL228 | IGF-1R , Bcr-Abl , Src , Aurora Kinase | |
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively). | |||
T63875 | Bosutinib hydrate | PF-5208763 hydrate,PF-05208763 hydrate,SKI-606 hydrate | Bcr-Abl , Src |
Bosutinib hydrate (SKI-606 hydrate) is an orally active and potent dual kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of Philadelphia Chromosome Positive Chronic Granulocytic Leukemia. | |||
T1448L | Dasatinib monohydrate | BMS-354825 Monohydrate | Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy |
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit... | |||
T1448 | Dasatinib | BMS-354825 | Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy |
Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitumor activity and is used in the treatment of leukemia and ly... | |||
T10962 | Dasatinib-d8 | BMS-354825 D8 | Others |
Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor. | |||
T64110 | Debio 0617B | ||
Debio 0617B is a multi-kinase inhibitor that reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. debio 0617B targets key kinases upstream of STAT3/STAT5 signalling, such as JAK, ABL, SR... | |||
T68581 | AP23464 | ||
AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ab... |